Emodin(from Rheum emodi, a red-veined pie plant) costs a evacuant resin, 6-methyl-1,3,8-trihydroxyanthraquinone, from rhubarb, the English plantain and Nipponese Knotweed (Fallopia Camellia japonica syn. This review is an attempt to analyze the biological properties of emodin, a molecule offering a broad therapeutic window, which in future may become a member of anticancer armamentarium. Emodin attenuated weight gain initially during treatment but had no apparent effect on weight gain and locomotor activity thereafter. We conclude that emodin can both attenuate EGF receptor signaling and ameliorate behavioral deficits. The anthraquinone derivative emodin ameliorates neurobehavioral deficits of a rodent model for schizophrenia. In studies in obese mice, emodin limits the effect of glucocorticoids and may therefore ameliorate diabetes and insulin resistance. Cas number: 518-82-1. Genus Polygonum cuspidatum). The terminus may likewise consult to immoderate peerless of a serial publication of rationales isomeric with the emodin from rhubarb plant implant. Additionally, because of its quinone structure, emodin may interfere with electron transport process and in altering cellular redox status, which may account for its cytotoxic properties in different systems. However, there is no documentation available which reviews the biological activities of emodin, in particular, its growth inhibitory effects.
Emodin in rhubarb extracts may also have neuroprotective properties against glutamate toxicity, but in other studies it seems to increase inflammation and have other possible neurotoxic effects. Systematic name:9,10-Anthracenedione, 1,3,8-trihydroxy-6-methyl- (9CI).
Emodin (from Rheum emodi, a Himalayan rhubarb) is a purgative resin, 6-methyl-1,3,8-trihydroxyanthraquinone, from rhubarb and the buckthorn. Molecular weight: 270.237. The term may also refer to any one of a series of principles isomeric with the emodin of rhubarb. Molecular formulae: C15H10O5. Emodin is being studied as a potential agent that could reduce the impact of type 2 diabetes. It is a potent selective inhibitor of the enzyme 11β-HSD1. Systematic name:9,10-Anthracenedione, 1,3,8-trihydroxy-6-methyl- (9CI).
Emodin, first assigned to be a specific inhibitor of the protein tyrosine kinase p65lck, has now a number of cellular targets interacting with it.
Very useful information, thank you very much for sharing
ReplyDelete