Dihydrogeodin’s Systematic name:Benzoic acid, 2-(3,5-dichloro-2,6-dihydroxy-4-methylbenzoyl)-5-hydroxy-3-methoxy-, methyl ester (9CI). Copper-containing enzyme which converts dihydrogeodin to (+)-geodin by an intramolecular phenol oxidative coupling reaction; isolated from aspergillus terreus Registry number: EC 1.10.3 .- (26 Jun 1999). Molecular formulae:C17H14Cl2O7. The purified enzyme showed an intense blue color and had absorption maxima at 280 and 600 nm, which suggested it to be a blue copper protein.
The enzyme named dihydrogeodin oxidase catalyzes the regio- and stereospecific phenol oxidative coupling reaction to form (+)-geodin from dihydrogeodin. The enzyme was purified from the cell-free extract of Aspergilus terreus , a (+)-geodin producer, by ammonium sulfate fractionation, acid treatment, and column chromatographies on DEAE-cellulose, Hydroxyapatite, chromatofocusing, and Toyopearl HW-55S. The purified enzyme was homogeneous as judged by sodium dodecyl sulfate polyacrylamide gel electrophoresis.
Product discription:(+)-Geodin was isolated from Penicillium glabrum AJ117540 with activity that stimulates glucose uptake by rat adipocytes. Cas number:2151-16-8. Unlike insulin it is active in the presence of wortmannin.Dihydrogeodin and sulochrin which are the precursors of (+)-geodin biosynthesis were also isolated from the same fungus. The molecular weight of the enzyme was estimated to be 153,000 by gel filtration on a Toyopearl HW-55S column and 76,000 by SDS-polyacrylamide gel electrophoresis, indicating that the enzyme is a dimer.
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