The function of ATF2 (phospho-Ser322) Polyclonal Antibody

ATF2 (phospho-Ser322) Polyclonal Antibody is aerial polyclonal antibiotic aloft adjoin constructed phosphopeptides of ATF2. This gene encodes a archetype agency that is a affiliate of the leucine attachment ancestors of DNA bounden proteins. This protein binds to the cAMP-responsive aspect (CRE), an octameric palindrome. The protein forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. The protein is aswell a histone acetyltransferase (HAT) that accurately acetylates histones H2B and H4 in vitro; appropriately it may represent a chic of sequence-specific factors that actuate archetype by absolute furnishings on chromatin components. Additional archetype variants accept been articular but their biological authority has not been determined. The gene atf2 is amid at animal chromosome 2q32. The protein ATF-2 has 505 amino acids. Studies in mice announce a role for ATF-2 in the development of afraid arrangement and the skeleton. ATF-2 is commonly activated in acknowledgment to signals that assemble on stress-activated protein kinases p38 and JNK. ATF-2 phosphorylation in acknowledgment to analysis of beef with bump apostle phorbol ester has been demonstrated. For analysis use only, not for analytic or ameliorative use.

Several studies accuse aberrant activation of ATF-2 in advance and progression of beastly derma tumors. ATF-2 may arbitrate oncogenesis acquired by aberrant Ras protein and adapt aliment of the advancing blight phenotype of some types of epithelial cells. ATF2 has aswell been apparent to be phosphorylated at its C-terminal (Serine 472 and 480 in mouse; Serine 490 and 498 in human) by ATM aloft double-stranded breaks. Mice with mutations of these two serines are acute to betterment and easier to tumorigenesis beneath p53 knockout background. ATF2 has aswell been apparent to be phosphorylated at its C-terminal (serine residues on p300 472 and 480 in mouse; serine residues on p300 490 and 498 in human) by ATM aloft double-stranded breaks. polyclonal antibiotic by the heterologous antigens (macromolecular antigen bisected antigen conjugates) to activate the physique to aftermath an allowed response, the animal claret beef bury a accumulation of immunoglobulin. Polyclonal antibiotic back it can analyze a advantage of antigen epitopes, can could cause the precipitation reaction, the alertness time is short, the affidavit of low amount is broadly acclimated in analysis and analytic aspects. The actuality can be acclimated as an antigen there are abounding accepted accurate experiments, common use of antigen: peptides accompanying conjugated baby atom or compound, accustomed or recombinant protein, etc.

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